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Any mental disorder

DOID EFO Endpoint Browser PheWeb

KRA_PSY_ANYMENTAL

vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F0[0-3]|F051|G30|F[1-9]
  • Hospital discharge: ICD-9 — 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A
  • Hospital discharge: ICD-8 — 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310
  • Cause of death: ICD-10 — F0[0-3]|F051|G30|F[1-9]
  • Cause of death: ICD-9 — 29[0-2]|2941A|29[5-9]|30|31[2-9]|3310A|3311A|4378A
  • Cause of death: ICD-8 — 29[0-1]|29440|29[5-9]|30[0-1]|3021|30[3-8]|310

2 out of 7 registries used, show all original rules.

127519

4. Check minimum number of events

None

127519

5. Include endpoints

128739

6. Filter based on genotype QC (FinnGen only)

123273

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1752582 883234 853645
Only index persons 1407999 748063 659936
Unadjusted period prevalence (%)
Whole population 24.51 25.30 23.85
Only index persons 26.42 27.50 25.19
Median age at first event (years)
Whole population 40.42 43.71 36.80
Only index persons 37.04 39.98 33.71

-FinnGen-

Key figures

All Female Male
Number of individuals 123273 71272 52001
Unadjusted period prevalence (%) 27.20 27.99 26.12
Median age at first event (years) 42.36 38.85 47.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_ANYMENTAL and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_ANYMENTAL 2.698 [2.51, 2.9] < 0.001
Birth year 0.983 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 143420 out of 609488 females with KRA_PSY_ANYMENTAL died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_ANYMENTAL 3.194 [2.94, 3.48] < 0.001
Birth year 0.979 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 121373 out of 527573 males with KRA_PSY_ANYMENTAL died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_ANYMENTAL.

N-year risk Females Males
1 0.117% 0.245%
5 0.699% 1.727%
10 1.767% 4.522%
15 3.293% 8.573%
20 5.577% 14.132%

Relationships between endpoints

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Index endpoint: KRA_PSY_ANYMENTAL – Any mental disorder

GWS hits: 27

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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