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Anxiety disorders

Endpoint Browser PheWeb

KRA_PSY_ANXIETY_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F40-F48
  • Hospital discharge: ICD-9 — 300[0-3|6-9]|3078A|309
  • Hospital discharge: ICD-8 — 300[0-2]|30030|300[5-9]|305|30680|30799
  • Cause of death: ICD-10 — F40-F48
  • Cause of death: ICD-9 — 300[0-3|6-9]|3078A|309
  • Cause of death: ICD-8 — 300[0-2]|30030|300[5-9]|305|30680|30799

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 534702 319646 211486
Only index persons 494695 301970 192725
Unadjusted period prevalence (%)
Whole population 7.84 9.16 5.91
Only index persons 9.64 11.10 7.36
Median age at first event (years)
Whole population 31.24 32.68 28.98
Only index persons 30.42 31.83 28.21

-FinnGen-

Key figures

All Female Male
Number of individuals 50486 34894 15592
Unadjusted period prevalence (%) 11.89 13.70 7.83
Median age at first event (years) 36.76 36.28 37.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_ANXIETY_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_ANXIETY_EXMORE 1.89 [1.7, 2.09] < 0.001
Birth year 0.99 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 18891 out of 236874 females with KRA_PSY_ANXIETY_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_ANXIETY_EXMORE 2.194 [1.99, 2.42] < 0.001
Birth year 0.988 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 15452 out of 142433 males with KRA_PSY_ANXIETY_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_ANXIETY_EXMORE.

N-year risk Females Males
1 0.16% 0.351%
5 0.819% 2.365%
10 2.079% 6.204%
15 4.01% 11.899%
20 7.188% 19.14%

Relationships between endpoints

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Index endpoint: KRA_PSY_ANXIETY_EXMORE – Anxiety disorders

GWS hits: 17

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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