anxiety disorder: A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
22889 |
4. Check minimum number of eventsNone |
22889 |
5. Include endpointsNone |
22889 |
6. Filter based on genotype QC (FinnGen only) |
21792 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other anxiety disorders
based on the number of shared cases.
Similar with more cases:
- Anxiety (asthma-related co-morbidities)
- All anxiety disorders
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 228957 | 142343 | 85191 |
| Only index persons | 216930 | 137437 | 79493 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.43 | 4.08 | 2.38 |
| Only index persons | 4.31 | 5.05 | 3.03 |
| Median age at first event (years) | |||
| Whole population | 29.44 | 29.54 | 29.18 |
| Only index persons | 28.89 | 29.00 | 28.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 21792 | 15416 | 6376 |
| Unadjusted period prevalence (%) | 5.22 | 6.05 | 3.20 |
| Median age at first event (years) | 35.05 | 34.40 | 36.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_ANXIETY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ANXIETY | 1.817 [1.63, 2.02] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.122 |
During the follow-up period (1.1.1998 — 31.12.2019), 7547 out of 106374 females with F5_ANXIETY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ANXIETY | 2.42 [2.16, 2.71] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 6071 out of 58879 males with F5_ANXIETY died.
Mortality risk
Mortality risk for people of age
years, who have F5_ANXIETY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.413% |
| 5 | 0.904% | 2.739% |
| 10 | 2.375% | 6.765% |
| 15 | 4.617% | 12.088% |
| 20 | 7.929% | 20.482% |
Relationships between endpoints
↥Index endpoint: F5_ANXIETY – Other anxiety disorders
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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