anxiety disorder: A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
33324 |
6. Filter based on genotype QC (FinnGen only) |
31780 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
All anxiety disorders
based on the number of shared cases.
Similar with more cases:
- Anxiety (asthma-related co-morbidities)
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
- Any mental disorder
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 347111 | 210940 | 134201 |
| Only index persons | 328303 | 202993 | 125310 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.13 | 6.04 | 3.75 |
| Only index persons | 6.44 | 7.46 | 4.78 |
| Median age at first event (years) | |||
| Whole population | 29.17 | 29.49 | 28.58 |
| Only index persons | 28.72 | 29.04 | 28.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 31780 | 22237 | 9543 |
| Unadjusted period prevalence (%) | 7.55 | 8.73 | 4.79 |
| Median age at first event (years) | 34.97 | 34.14 | 36.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_ALLANXIOUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ALLANXIOUS | 1.961 [1.75, 2.2] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.286 |
During the follow-up period (1.1.1998 — 31.12.2019), 10671 out of 159039 females with F5_ALLANXIOUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ALLANXIOUS | 2.404 [2.17, 2.66] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 9065 out of 96692 males with F5_ALLANXIOUS died.
Mortality risk
Mortality risk for people of age
years, who have F5_ALLANXIOUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.135% | 0.454% |
| 5 | 1.035% | 2.702% |
| 10 | 2.802% | 7.019% |
| 15 | 5.418% | 13.054% |
| 20 | 9.573% | 21.583% |
Relationships between endpoints
↥Index endpoint: F5_ALLANXIOUS – All anxiety disorders
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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