phobic disorder: An anxiety disorder characterized by an intense, irrational fear of an object, activity, or situation. The individual seeks to avoid the object, activity, or situation. In adults, the individual recognizes that the fear is excessive or unreasonable.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5763 |
4. Check minimum number of eventsNone |
5763 |
5. Include endpoints |
5763 |
6. Filter based on genotype QC (FinnGen only) |
5534 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F40-F48
Name in latin
Perturbationes anxiferae phobicae
Similar endpoints
↥List of similar endpoints to
Phobic anxiety disorders
based on the number of shared cases.
Similar with more cases:
- Anxiety (asthma-related co-morbidities)
- All anxiety disorders
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 71160 | 39546 | 31408 |
| Only index persons | 67745 | 38143 | 29602 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.02 | 1.13 | 0.88 |
| Only index persons | 1.28 | 1.40 | 1.13 |
| Median age at first event (years) | |||
| Whole population | 25.01 | 24.47 | 25.64 |
| Only index persons | 25.02 | 24.50 | 25.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5534 | 3694 | 1840 |
| Unadjusted period prevalence (%) | 1.28 | 1.45 | 0.92 |
| Median age at first event (years) | 31.60 | 30.52 | 33.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_PHOBANX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PHOBANX | 2.149 [1.83, 2.52] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.27 |
During the follow-up period (1.1.1998 — 31.12.2019), 1311 out of 31007 females with F5_PHOBANX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PHOBANX | 2.545 [2.25, 2.87] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 1792 out of 25156 males with F5_PHOBANX died.
Mortality risk
Mortality risk for people of age
years, who have F5_PHOBANX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.254% | 0.454% |
| 5 | 1.241% | 2.761% |
| 10 | 3.237% | 6.986% |
| 15 | 6.009% | 13.579% |
| 20 | 10.585% | 21.868% |
Relationships between endpoints
↥Index endpoint: F5_PHOBANX – Phobic anxiety disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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