No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1197 |
4. Check minimum number of eventsNone |
1197 |
5. Include endpointsNone |
1197 |
6. Filter based on genotype QC (FinnGen only) |
1153 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF6
Similar endpoints
↥List of similar endpoints to
Agoraphobia
based on the number of shared cases.
Similar with more cases:
- Phobic anxiety disorders
- All anxiety disorders
- Anxiety (asthma-related co-morbidities)
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11811 | 6982 | 4784 |
| Only index persons | 11568 | 6897 | 4671 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.20 | 0.13 |
| Only index persons | 0.22 | 0.25 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 28.70 | 27.94 | 29.78 |
| Only index persons | 28.56 | 27.81 | 29.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1153 | 818 | 335 |
| Unadjusted period prevalence (%) | 0.28 | 0.32 | 0.17 |
| Median age at first event (years) | 33.52 | 32.91 | 35.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_AGORAPHOBIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_AGORAPHOBIA | 2.744 [2.29, 3.28] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.093 |
During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 5608 females with F5_AGORAPHOBIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_AGORAPHOBIA | 3.445 [2.92, 4.06] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 3918 males with F5_AGORAPHOBIA died.
Mortality risk
Mortality risk for people of age
years, who have F5_AGORAPHOBIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.205% | 0.541% |
| 5 | 1.563% | 3.646% |
| 10 | 3.817% | 8.907% |
| 15 | 6.964% | 16.043% |
| 20 | 11.93% | 26.285% |
Relationships between endpoints
↥Index endpoint: F5_AGORAPHOBIA – Agoraphobia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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