generalized anxiety disorder: An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6488 |
4. Check minimum number of eventsNone |
6488 |
5. Include endpointsNone |
6488 |
6. Filter based on genotype QC (FinnGen only) |
6242 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F41
Name in latin
Perturbatio anxifera generalisata
Similar endpoints
↥List of similar endpoints to
Generalized anxiety disorder
based on the number of shared cases.
Similar with more cases:
- Anxiety (asthma-related co-morbidities)
- All anxiety disorders
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 55293 | 36531 | 18494 |
| Only index persons | 53023 | 35440 | 17583 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.87 | 1.05 | 0.52 |
| Only index persons | 1.09 | 1.30 | 0.67 |
| Median age at first event (years) | |||
| Whole population | 34.12 | 33.83 | 34.65 |
| Only index persons | 33.53 | 33.25 | 34.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6242 | 4591 | 1651 |
| Unadjusted period prevalence (%) | 1.55 | 1.80 | 0.83 |
| Median age at first event (years) | 37.83 | 36.86 | 40.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_GAD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_GAD | 1.792 [1.57, 2.04] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.718 |
During the follow-up period (1.1.1998 — 31.12.2019), 1687 out of 25503 females with F5_GAD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_GAD | 2.126 [1.86, 2.43] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 1274 out of 13223 males with F5_GAD died.
Mortality risk
Mortality risk for people of age
years, who have F5_GAD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.228% | 0.338% |
| 5 | 1.164% | 2.608% |
| 10 | 2.879% | 6.777% |
| 15 | 5.653% | 12.836% |
| 20 | 10.208% | 20.982% |
Relationships between endpoints
↥Index endpoint: F5_GAD – Generalized anxiety disorder
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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