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Obsessive-compulsive disorder

DOID EFO Endpoint Browser PheWeb

F5_OCD

obsessive-compulsive disorder: A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F42
  • Hospital discharge: ICD-9 — 3003
  • Hospital discharge: ICD-8 — 3003
  • Cause of death: ICD-10 — F42
  • Cause of death: ICD-9 — 3003
  • Cause of death: ICD-8 — 3003

2 out of 7 registries used, show all original rules.

2614

4. Check minimum number of events

None

2614

5. Include endpoints

None

2614

6. Filter based on genotype QC (FinnGen only)

2490

Control definitions (FinnGen only)

Control exclude F5_NEUROTIC

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F40-F48
Name in latin Perturbatio obsessivo-compulsiva

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 29148 16764 12270
Only index persons 27884 16218 11666
Unadjusted period prevalence (%)
Whole population 0.42 0.48 0.34
Only index persons 0.53 0.60 0.45
Median age at first event (years)
Whole population 24.97 25.04 24.81
Only index persons 24.80 24.90 24.66

-FinnGen-

Key figures

All Female Male
Number of individuals 2490 1656 834
Unadjusted period prevalence (%) 0.57 0.65 0.42
Median age at first event (years) 29.85 28.96 31.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_OCD and mortality.

Females

Parameter HR [95% CI] p-value
F5_OCD 1.938 [1.63, 2.3] < 0.001
Birth year 0.993 [0.98, 1.0] 0.116

During the follow-up period (1.1.1998 — 31.12.2019), 472 out of 12309 females with F5_OCD died.

Males

Parameter HR [95% CI] p-value
F5_OCD 1.986 [1.7, 2.32] < 0.001
Birth year 0.988 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 518 out of 9308 males with F5_OCD died.

Mortality risk

Mortality risk for people of age

years, who have F5_OCD.

N-year risk Females Males
1 0.158% 0.356%
5 0.983% 2.309%
10 2.729% 5.583%
15 4.791% 10.558%
20 8.618% 18.104%

Relationships between endpoints

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Index endpoint: F5_OCD – Obsessive-compulsive disorder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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