panic disorder: An anxiety disorder characterized by multiple unexpected panic attacks with persistent concern of recurring attacks. Panic disorder may or may not be accompanied by agoraphobia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6468 |
4. Check minimum number of eventsNone |
6468 |
5. Include endpointsNone |
6468 |
6. Filter based on genotype QC (FinnGen only) |
6142 |
Control definitions (FinnGen only)
Control exclude
F5_NEUROTIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F41
Name in latin
Angor paroxysmalis episodicus
Similar endpoints
↥List of similar endpoints to
Panic disorder
based on the number of shared cases.
Similar with more cases:
- Anxiety (asthma-related co-morbidities)
- All anxiety disorders
- Neurotic, stress-related and somatoform disorders
- Anxiety disorders
- Anxiety disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 63306 | 40160 | 22748 |
| Only index persons | 60929 | 39122 | 21807 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.96 | 1.15 | 0.64 |
| Only index persons | 1.22 | 1.44 | 0.83 |
| Median age at first event (years) | |||
| Whole population | 31.41 | 31.13 | 31.88 |
| Only index persons | 31.03 | 30.75 | 31.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6142 | 4462 | 1680 |
| Unadjusted period prevalence (%) | 1.50 | 1.75 | 0.84 |
| Median age at first event (years) | 34.63 | 32.92 | 39.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_PANIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PANIC | 1.924 [1.68, 2.21] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 2097 out of 32471 females with F5_PANIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_PANIC | 2.225 [1.96, 2.52] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 1636 out of 18221 males with F5_PANIC died.
Mortality risk
Mortality risk for people of age
years, who have F5_PANIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.451% |
| 5 | 0.849% | 2.809% |
| 10 | 2.11% | 6.844% |
| 15 | 4.265% | 12.757% |
| 20 | 7.272% | 21.233% |
Relationships between endpoints
↥Index endpoint: F5_PANIC – Panic disorder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data