No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
8319 |
6. Filter based on genotype QC (FinnGen only) |
7905 |
Control definitions (FinnGen only)
Control exclude
F5_SUBSTANCE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Substance use, excluding alcohol
based on the number of shared cases.
Similar with more cases:
- Substance abuse
- Substance abuse
- Mental and behavioural disorders due to psychoactive substance use
- Any mental disorder
- Psychiatric diseases
Similar with less cases:
- Mental and behavioural disorders due to tobacco
- Smoking dependency
- Mental and behavioural disorders due to multiple drug use and use of multiple drugs and use of other psychoactive substances
- Mental and behavioural disorders due to sedatives or hypnotics
- Mental and behavioural disorders due to opioids
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 98359 | 36314 | 61289 |
| Only index persons | 83970 | 32300 | 51670 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.46 | 1.04 | 1.71 |
| Only index persons | 1.67 | 1.19 | 1.97 |
| Median age at first event (years) | |||
| Whole population | 34.02 | 37.28 | 32.00 |
| Only index persons | 32.54 | 35.38 | 30.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7905 | 3740 | 4165 |
| Unadjusted period prevalence (%) | 1.80 | 1.47 | 2.09 |
| Median age at first event (years) | 39.89 | 40.09 | 39.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_SUBSNOALCO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SUBSNOALCO | 4.069 [3.6, 4.6] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.226 |
During the follow-up period (1.1.1998 — 31.12.2019), 4077 out of 26104 females with F5_SUBSNOALCO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_SUBSNOALCO | 5.055 [4.51, 5.66] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 8442 out of 42072 males with F5_SUBSNOALCO died.
Mortality risk
Mortality risk for people of age
years, who have F5_SUBSNOALCO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.455% | 0.677% |
| 5 | 1.947% | 4.471% |
| 10 | 5.294% | 12.143% |
| 15 | 10.551% | 21.481% |
| 20 | 17.583% | 34.883% |
Relationships between endpoints
↥Index endpoint: F5_SUBSNOALCO – Substance use, excluding alcohol
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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