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Mental and behavioural disorders due to use of other stimulants, including caffeine

DOID EFO Endpoint Browser PheWeb

F5_STIMUL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F15
  • Hospital discharge: ICD-9 — 3044|3057
  • Hospital discharge: ICD-8 — 3046
  • Cause of death: ICD-10 — F15
  • Cause of death: ICD-9 — 3044|3057
  • Cause of death: ICD-8 — 3046

2 out of 7 registries used, show all original rules.

1054

4. Check minimum number of events

None

1054

5. Include endpoints

None

1054

6. Filter based on genotype QC (FinnGen only)

987

Control definitions (FinnGen only)

Control exclude F5_SUBSNOALCO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10-F19
Name in latin Perturbationes mentis et modi se gerendi ex usu aliorum stimulantium (coffeino incluso)

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14032 4086 9842
Only index persons 12674 3871 8803
Unadjusted period prevalence (%)
Whole population 0.23 0.12 0.27
Only index persons 0.28 0.14 0.34
Median age at first event (years)
Whole population 26.36 24.29 27.19
Only index persons 26.26 24.21 27.15

-FinnGen-

Key figures

All Female Male
Number of individuals 987 395 592
Unadjusted period prevalence (%) 0.24 0.16 0.30
Median age at first event (years) 26.97 25.56 27.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_STIMUL and mortality.

Females

Parameter HR [95% CI] p-value
F5_STIMUL 9.742 [6.72, 14.13] < 0.001
Birth year 0.995 [0.99, 1.0] 0.242

During the follow-up period (1.1.1998 — 31.12.2019), 297 out of 3106 females with F5_STIMUL died.

Males

Parameter HR [95% CI] p-value
F5_STIMUL 9.704 [8.62, 10.92] < 0.001
Birth year 0.99 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 1150 out of 6957 males with F5_STIMUL died.

Mortality risk

Mortality risk for people of age

years, who have F5_STIMUL.

N-year risk Females Males
1 0.892% 1.823%
5 6.188% 10.148%
10 14.644% 25.694%
15 25.708% 45.373%
20 40.894% 65.742%

Relationships between endpoints

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Index endpoint: F5_STIMUL – Mental and behavioural disorders due to use of other stimulants, including caffeine

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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