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Mental and behavioural disorders due to sedatives or hypnotics

DOID EFO Endpoint Browser PheWeb

F5_SEDAHYP

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F13
  • Hospital discharge: ICD-9 — 3041|3054
  • Hospital discharge: ICD-8 — 304[2-3]
  • Cause of death: ICD-10 — F13
  • Cause of death: ICD-9 — 3041|3054
  • Cause of death: ICD-8 — 304[2-3]

2 out of 7 registries used, show all original rules.

2570

4. Check minimum number of events

None

2570

5. Include endpoints

None

2570

6. Filter based on genotype QC (FinnGen only)

2452

Control definitions (FinnGen only)

Control exclude F5_SUBSNOALCO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10-F19
Name in latin Perturbationes mentis et modi se gerendi ex usu sedativorum et hypnoticorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 32607 13097 19202
Only index persons 26203 11052 15151
Unadjusted period prevalence (%)
Whole population 0.47 0.38 0.54
Only index persons 0.51 0.41 0.58
Median age at first event (years)
Whole population 36.90 40.40 34.37
Only index persons 35.51 38.99 32.97

-FinnGen-

Key figures

All Female Male
Number of individuals 2452 1201 1251
Unadjusted period prevalence (%) 0.55 0.47 0.63
Median age at first event (years) 38.17 39.28 37.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_SEDAHYP and mortality.

Females

Parameter HR [95% CI] p-value
F5_SEDAHYP 3.381 [2.97, 3.85] < 0.001
Birth year 0.998 [0.99, 1.01] 0.634

During the follow-up period (1.1.1998 — 31.12.2019), 1658 out of 8754 females with F5_SEDAHYP died.

Males

Parameter HR [95% CI] p-value
F5_SEDAHYP 5.303 [4.66, 6.03] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 2915 out of 12504 males with F5_SEDAHYP died.

Mortality risk

Mortality risk for people of age

years, who have F5_SEDAHYP.

N-year risk Females Males
1 0.342% 0.843%
5 2.03% 5.691%
10 5.193% 13.837%
15 9.955% 25.629%
20 17.406% 39.956%

Relationships between endpoints

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Index endpoint: F5_SEDAHYP – Mental and behavioural disorders due to sedatives or hypnotics

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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