No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2848 |
4. Check minimum number of eventsNone |
2848 |
5. Include endpointsNone |
2848 |
6. Filter based on genotype QC (FinnGen only) |
2747 |
Control definitions (FinnGen only)
Control exclude
SMOKING
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F10-F19
Name in latin
Perturbationes mentis et modi se gerendi ex usu tabaci
Similar endpoints
↥List of similar endpoints to
Smoking dependency
based on the number of shared cases.
Similar with more cases:
- Mental and behavioural disorders due to tobacco
- Smoking
- Substance use, excluding alcohol
- Substance abuse
- Substance abuse
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20684 | 9243 | 11340 |
| Only index persons | 19695 | 8992 | 10703 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.26 | 0.32 |
| Only index persons | 0.37 | 0.33 | 0.41 |
| Median age at first event (years) | |||
| Whole population | 56.15 | 53.81 | 58.11 |
| Only index persons | 55.85 | 53.56 | 57.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2747 | 1423 | 1324 |
| Unadjusted period prevalence (%) | 0.61 | 0.56 | 0.66 |
| Median age at first event (years) | 55.86 | 52.77 | 59.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SMOKING_DEPEND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SMOKING_DEPEND | 4.286 [3.7, 4.96] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.387 |
During the follow-up period (1.1.1998 — 31.12.2019), 1128 out of 7610 females with SMOKING_DEPEND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SMOKING_DEPEND | 4.225 [3.68, 4.85] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2408 out of 9115 males with SMOKING_DEPEND died.
Mortality risk
Mortality risk for people of age
years, who have SMOKING_DEPEND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.4% | 0.781% |
| 5 | 2.348% | 4.83% |
| 10 | 6.354% | 10.518% |
| 15 | 12.486% | 19.903% |
| 20 | 21.332% | 31.389% |
Relationships between endpoints
↥Index endpoint: SMOKING_DEPEND – Smoking dependency
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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