Smoking

SMOKING

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

4442

6. Filter based on genotype QC (FinnGen only)

4271

Control definitions (FinnGen only)

Control exclude ASTHMA_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34751 16898 17703
Only index persons 33418 16544 16874
Unadjusted period prevalence (%)
Whole population 0.49 0.48 0.49
Only index persons 0.63 0.61 0.64
Median age at first event (years)
Whole population 53.76 49.18 58.21
Only index persons 53.42 48.77 57.98

-FinnGen-

Key figures

All Female Male
Number of individuals 4271 2216 2055
Unadjusted period prevalence (%) 0.95 0.87 1.03
Median age at first event (years) 55.10 51.33 59.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint SMOKING and mortality.

Females

Parameter HR [95% CI] p-value
SMOKING 4.248 [3.64, 4.95] < 0.001
Birth year 0.995 [0.99, 1.0] 0.223

During the follow-up period (1.1.1998 — 31.12.2019), 1644 out of 13938 females with SMOKING died.

Males

Parameter HR [95% CI] p-value
SMOKING 3.988 [3.49, 4.56] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 3487 out of 14174 males with SMOKING died.

Mortality risk

Mortality risk for people of age

years, who have SMOKING.

N-year risk Females Males
1 0.38% 0.535%
5 2.336% 3.353%
10 5.908% 9.596%
15 11.395% 18.337%
20 19.993% 29.903%

Relationships between endpoints

Index endpoint: SMOKING – Smoking

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data