No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1730 |
4. Check minimum number of eventsNone |
1730 |
5. Include endpointsNone |
1730 |
6. Filter based on genotype QC (FinnGen only) |
1654 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
Special
TOBACCO_USE
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z72
Similar endpoints
↥List of similar endpoints to
Tobacco use
based on the number of shared cases.
Similar with more cases:
- Problems related to lifestyle
- Smoking
- Persons encountering health services in other circumstances
- Excluding asthma or asthma-COPD overlap
- Factors influencing health status and contact with health services
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15107 | 8245 | 6808 |
| Only index persons | 14765 | 8149 | 6616 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.24 | 0.19 |
| Only index persons | 0.28 | 0.30 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 47.75 | 38.80 | 58.70 |
| Only index persons | 47.47 | 38.45 | 58.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1654 | 871 | 783 |
| Unadjusted period prevalence (%) | 0.37 | 0.34 | 0.39 |
| Median age at first event (years) | 52.69 | 46.88 | 59.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint Z21_TOBAC_USE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Z21_TOBAC_USE | 4.091 [3.36, 4.98] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 563 out of 6759 females with Z21_TOBAC_USE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Z21_TOBAC_USE | 3.572 [3.04, 4.19] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 1187 out of 5385 males with Z21_TOBAC_USE died.
Mortality risk
Mortality risk for people of age
years, who have Z21_TOBAC_USE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.354% | 0.697% |
| 5 | 1.971% | 4.435% |
| 10 | 4.785% | 10.632% |
| 15 | 9.024% | 19.49% |
| 20 | 15.459% | 32.185% |
Relationships between endpoints
↥Index endpoint: Z21_TOBAC_USE – Tobacco use
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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