Mental and behavioural disorders due to hallucinogens

F5_HALLUCIN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F16
  • Hospital discharge: ICD-9 3045|3053
  • Hospital discharge: ICD-8 3047
  • Cause of death: ICD-10 F16
  • Cause of death: ICD-9 3045|3053
  • Cause of death: ICD-8 3047

2 out of 7 registries used, show all original rules.

188

4. Check minimum number of events

None

188

5. Include endpoints

None

188

6. Filter based on genotype QC (FinnGen only)

168

Control definitions (FinnGen only)

Control exclude F5_SUBSNOALCO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10-F19
Name in latin Perturbationes mentis et modi se gerendi ex usu hallucinogenum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2511 605 1885
Only index persons 2244 557 1687
Unadjusted period prevalence (%)
Whole population 0.04 0.02 0.05
Only index persons 0.05 0.02 0.06
Median age at first event (years)
Whole population 24.55 23.22 24.95
Only index persons 24.23 23.08 24.61

-FinnGen-

Key figures

All Female Male
Number of individuals 168 54 114
Unadjusted period prevalence (%) 0.05 0.02 0.06
Median age at first event (years) 25.52 25.29 25.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint F5_HALLUCIN and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
F5_HALLUCIN 9.052 [6.5, 12.62] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 1407 males with F5_HALLUCIN died.

Mortality risk

Mortality risk for people of age

years, who have F5_HALLUCIN.

N-year risk Females Males
1 No data 1.919%
5 No data 10.149%
10 No data 22.265%
15 No data 38.274%
20 No data 56.046%

Relationships between endpoints

Index endpoint: F5_HALLUCIN – Mental and behavioural disorders due to hallucinogens

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data