opioid dependence: Disorders related or resulting from abuse or mis-use of opioids.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1397 |
4. Check minimum number of eventsNone |
1397 |
5. Include endpointsNone |
1397 |
6. Filter based on genotype QC (FinnGen only) |
1312 |
Control definitions (FinnGen only)
Control exclude
F5_SUBSNOALCO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F10-F19
Name in latin
Perturbationes mentis et modi se gerendi ex usu opioidum
Similar endpoints
↥List of similar endpoints to
Mental and behavioural disorders due to opioids
based on the number of shared cases.
Similar with more cases:
- Substance use, excluding alcohol
- Substance abuse
- Substance abuse
- Mental and behavioural disorders due to psychoactive substance use
- Exclusions for E4_PCOS_CONSORTIUM
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18149 | 6045 | 11977 |
| Only index persons | 16497 | 5574 | 10923 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.17 | 0.33 |
| Only index persons | 0.35 | 0.20 | 0.42 |
| Median age at first event (years) | |||
| Whole population | 29.82 | 29.12 | 30.11 |
| Only index persons | 29.40 | 28.45 | 29.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1312 | 584 | 728 |
| Unadjusted period prevalence (%) | 0.30 | 0.23 | 0.37 |
| Median age at first event (years) | 31.70 | 31.41 | 31.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_OPIOIDS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_OPIOIDS | 4.677 [3.71, 5.89] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.412 |
During the follow-up period (1.1.1998 — 31.12.2019), 741 out of 4868 females with F5_OPIOIDS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_OPIOIDS | 7.027 [5.93, 8.33] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 1696 out of 9514 males with F5_OPIOIDS died.
Mortality risk
Mortality risk for people of age
years, who have F5_OPIOIDS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.526% | 1.405% |
| 5 | 3.115% | 8.123% |
| 10 | 6.978% | 19.772% |
| 15 | 12.71% | 34.813% |
| 20 | 21.802% | 52.633% |
Relationships between endpoints
↥Index endpoint: F5_OPIOIDS – Mental and behavioural disorders due to opioids
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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