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Mental and behavioural disorders due to multiple drug use and use of multiple drugs and use of other psychoactive substances

DOID EFO Endpoint Browser PheWeb

F5_OTHERSUB

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F19
  • Hospital discharge: ICD-9 — 3059|3049
  • Hospital discharge: ICD-8 — 304[8-9]
  • Cause of death: ICD-10 — F19
  • Cause of death: ICD-9 — 3059|3049
  • Cause of death: ICD-8 — 304[8-9]

2 out of 7 registries used, show all original rules.

2822

4. Check minimum number of events

None

2822

5. Include endpoints

None

2822

6. Filter based on genotype QC (FinnGen only)

2649

Control definitions (FinnGen only)

Control exclude F5_SUBSNOALCO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10-F19
Name in latin Perturbationes mentis et modi se gerendi ex usu medicamentorum multorum et aliarum substantiarum psychotropicarum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 40059 12579 27166
Only index persons 33514 10977 22537
Unadjusted period prevalence (%)
Whole population 0.63 0.36 0.76
Only index persons 0.71 0.40 0.86
Median age at first event (years)
Whole population 27.93 27.54 28.02
Only index persons 26.73 26.08 27.05

-FinnGen-

Key figures

All Female Male
Number of individuals 2649 1061 1588
Unadjusted period prevalence (%) 0.64 0.42 0.80
Median age at first event (years) 28.32 28.09 28.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_OTHERSUB and mortality.

Females

Parameter HR [95% CI] p-value
F5_OTHERSUB 6.139 [5.14, 7.33] < 0.001
Birth year 0.995 [0.99, 1.0] 0.196

During the follow-up period (1.1.1998 — 31.12.2019), 1204 out of 8634 females with F5_OTHERSUB died.

Males

Parameter HR [95% CI] p-value
F5_OTHERSUB 8.414 [7.42, 9.54] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3406 out of 17953 males with F5_OTHERSUB died.

Mortality risk

Mortality risk for people of age

years, who have F5_OTHERSUB.

N-year risk Females Males
1 0.465% 1.578%
5 3.263% 8.644%
10 7.707% 20.042%
15 15.191% 35.654%
20 25.429% 55.029%

Relationships between endpoints

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Index endpoint: F5_OTHERSUB – Mental and behavioural disorders due to multiple drug use and use of multiple drugs and use of other psychoactive substances

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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