cannabis dependence: Physical and psychological dependence on the drug cannabis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1172 |
4. Check minimum number of eventsNone |
1172 |
5. Include endpointsNone |
1172 |
6. Filter based on genotype QC (FinnGen only) |
1083 |
Control definitions (FinnGen only)
Control exclude
F5_SUBSNOALCO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F10-F19
Name in latin
Perturbationes mentis et modi se gerendi ex usu cannabinoidum
Similar endpoints
↥List of similar endpoints to
Mental and behavioural disorders due to cannabinoids
based on the number of shared cases.
Similar with more cases:
- Substance use, excluding alcohol
- Substance abuse
- Substance abuse
- Mental and behavioural disorders due to psychoactive substance use
- Any mental disorder
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16485 | 3931 | 12473 |
| Only index persons | 15328 | 3776 | 11552 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.11 | 0.35 |
| Only index persons | 0.37 | 0.14 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 23.76 | 22.13 | 24.23 |
| Only index persons | 23.61 | 22.05 | 24.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1083 | 343 | 740 |
| Unadjusted period prevalence (%) | 0.30 | 0.13 | 0.37 |
| Median age at first event (years) | 25.28 | 24.59 | 25.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_CANNABIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_CANNABIS | 10.921 [7.35, 16.22] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.928 |
During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 3066 females with F5_CANNABIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_CANNABIS | 7.831 [6.98, 8.79] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 971 out of 9587 males with F5_CANNABIS died.
Mortality risk
Mortality risk for people of age
years, who have F5_CANNABIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.23% | 1.34% |
| 5 | 7.057% | 8.863% |
| 10 | 15.849% | 21.207% |
| 15 | 28.471% | 35.437% |
| 20 | 45.872% | 53.733% |
Relationships between endpoints
↥Index endpoint: F5_CANNABIS – Mental and behavioural disorders due to cannabinoids
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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