alcoholic pancreatitis: Acute or chronic inflammation of the pancreas due to excessive alcohol drinking. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2214 |
4. Check minimum number of eventsNone |
2214 |
5. Include endpointsNone |
2214 |
6. Filter based on genotype QC (FinnGen only) |
2158 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Alcohol-induced chronic pancreatitis
based on the number of shared cases.
Similar with more cases:
- Chronic pancreatitis
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Disorders of gallbladder, biliary tract and pancreas
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26565 | 4781 | 21551 |
| Only index persons | 20455 | 3883 | 16572 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.52 | 0.14 | 0.60 |
| Only index persons | 0.54 | 0.14 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 49.32 | 50.76 | 48.95 |
| Only index persons | 49.19 | 50.78 | 48.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2158 | 456 | 1702 |
| Unadjusted period prevalence (%) | 0.71 | 0.18 | 0.85 |
| Median age at first event (years) | 50.68 | 49.86 | 50.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ALCOPANCCHRON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALCOPANCCHRON | 4.813 [4.18, 5.54] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 1169 out of 3550 females with ALCOPANCCHRON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALCOPANCCHRON | 4.315 [3.99, 4.66] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 5723 out of 15453 males with ALCOPANCCHRON died.
Mortality risk
Mortality risk for people of age
years, who have ALCOPANCCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.42% | 0.927% |
| 5 | 2.799% | 5.219% |
| 10 | 6.305% | 12.083% |
| 15 | 11.637% | 21.346% |
| 20 | 20.37% | 34.41% |
Relationships between endpoints
↥Index endpoint: ALCOPANCCHRON – Alcohol-induced chronic pancreatitis
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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