alcoholic pancreatitis: Acute or chronic inflammation of the pancreas due to excessive alcohol drinking. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
4337 |
4. Check minimum number of eventsNone |
4337 |
5. Include endpointsNone |
4337 |
6. Filter based on genotype QC (FinnGen only) |
4222 |
Control definitions (FinnGen only)
Control exclude
K11_GALLBILPANC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Chronic pancreatitis
based on the number of shared cases.
Similar with more cases:
- Disorders of gallbladder, biliary tract and pancreas
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 41461 | 11321 | 29733 |
| Only index persons | 32317 | 9387 | 22930 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.69 | 0.32 | 0.83 |
| Only index persons | 0.72 | 0.35 | 0.88 |
| Median age at first event (years) | |||
| Whole population | 53.49 | 58.70 | 51.48 |
| Only index persons | 53.93 | 58.91 | 51.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4222 | 1342 | 2880 |
| Unadjusted period prevalence (%) | 1.15 | 0.53 | 1.45 |
| Median age at first event (years) | 56.71 | 58.30 | 55.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_CHRONPANC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHRONPANC | 4.363 [3.88, 4.9] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.197 |
During the follow-up period (1.1.1998 — 31.12.2019), 3230 out of 8097 females with K11_CHRONPANC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHRONPANC | 4.37 [3.99, 4.79] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 8192 out of 20710 males with K11_CHRONPANC died.
Mortality risk
Mortality risk for people of age
years, who have K11_CHRONPANC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.393% | 0.649% |
| 5 | 2.528% | 4.404% |
| 10 | 6.237% | 10.43% |
| 15 | 12.667% | 19.633% |
| 20 | 19.991% | 31.006% |
Relationships between endpoints
↥Index endpoint: K11_CHRONPANC – Chronic pancreatitis
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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