Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3413 |
4. Check minimum number of eventsNone |
3413 |
5. Include endpointsNone |
3413 |
6. Filter based on genotype QC (FinnGen only) |
3330 |
Control definitions (FinnGen only)
Control exclude
K11_LIVER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K70-K77
Name in latin
Morbus hepatis alcoholicus
Similar endpoints
↥List of similar endpoints to
Alcoholic liver disease
based on the number of shared cases.
Similar with more cases:
- Alcoholic liver disease
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Diseases of liver
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 68208 | 15821 | 50693 |
| Only index persons | 38268 | 9865 | 28403 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.20 | 0.45 | 1.42 |
| Only index persons | 0.90 | 0.36 | 1.08 |
| Median age at first event (years) | |||
| Whole population | 55.72 | 56.23 | 55.54 |
| Only index persons | 57.44 | 57.56 | 57.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3330 | 826 | 2504 |
| Unadjusted period prevalence (%) | 1.03 | 0.32 | 1.26 |
| Median age at first event (years) | 58.37 | 56.20 | 59.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_ALCOLIV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ALCOLIV | 11.697 [10.45, 13.1] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 3976 out of 7562 females with K11_ALCOLIV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ALCOLIV | 9.976 [8.99, 11.08] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 11841 out of 19918 males with K11_ALCOLIV died.
Mortality risk
Mortality risk for people of age
years, who have K11_ALCOLIV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.184% | 1.812% |
| 5 | 5.878% | 9.395% |
| 10 | 15.011% | 23.72% |
| 15 | 26.759% | 40.975% |
| 20 | 41.307% | 60.919% |
Relationships between endpoints
↥Index endpoint: K11_ALCOLIV – Alcoholic liver disease
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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