liver disease: A disease involving the liver.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
12795 |
4. Check minimum number of eventsNone |
12795 |
5. Include endpoints |
13920 |
6. Filter based on genotype QC (FinnGen only) |
13432 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Diseases of liver
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 150473 | 59607 | 88221 |
| Only index persons | 105531 | 46647 | 58884 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.17 | 1.71 | 2.46 |
| Only index persons | 2.01 | 1.71 | 2.25 |
| Median age at first event (years) | |||
| Whole population | 55.75 | 57.08 | 54.83 |
| Only index persons | 55.80 | 56.49 | 55.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13432 | 6662 | 6770 |
| Unadjusted period prevalence (%) | 3.01 | 2.62 | 3.40 |
| Median age at first event (years) | 55.65 | 54.41 | 56.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_LIVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_LIVER | 3.269 [2.98, 3.59] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 10429 out of 36669 females with K11_LIVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_LIVER | 5.394 [4.85, 6.0] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 18403 out of 43303 males with K11_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have K11_LIVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.298% | 0.756% |
| 5 | 1.544% | 5.108% |
| 10 | 3.989% | 12.745% |
| 15 | 7.147% | 23.705% |
| 20 | 12.7% | 37.641% |
Relationships between endpoints
↥Index endpoint: K11_LIVER – Diseases of liver
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data