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Hepatic failure, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

K11_HEPFAIL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K72
  • Hospital discharge: ICD-9 — 570
  • Hospital discharge: ICD-8 — 570
  • Hospital discharge: excluded ICD-8 — 57001
  • Cause of death: ICD-10 — K72
  • Cause of death: ICD-9 — 570
  • Cause of death: ICD-8 — 570
  • Cause of death: excluded ICD-8 — 57001

2 out of 7 registries used, show all original rules.

1152

4. Check minimum number of events

None

1152

5. Include endpoints

None

1152

6. Filter based on genotype QC (FinnGen only)

1123

Control definitions (FinnGen only)

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Insufficientia hepatis non alibi classificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13134 5721 7234
Only index persons 9949 4454 5495
Unadjusted period prevalence (%)
Whole population 0.19 0.16 0.20
Only index persons 0.19 0.16 0.21
Median age at first event (years)
Whole population 60.26 60.66 59.96
Only index persons 60.52 60.24 60.75

-FinnGen-

Key figures

All Female Male
Number of individuals 1123 518 605
Unadjusted period prevalence (%) 0.26 0.20 0.30
Median age at first event (years) 59.30 56.30 61.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_HEPFAIL and mortality.

Females

Parameter HR [95% CI] p-value
K11_HEPFAIL 5.676 [4.64, 6.95] < 0.001
Birth year 0.999 [0.99, 1.01] 0.734

During the follow-up period (1.1.1998 — 31.12.2019), 1261 out of 2843 females with K11_HEPFAIL died.

Males

Parameter HR [95% CI] p-value
K11_HEPFAIL 8.309 [6.57, 10.51] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 1973 out of 3664 males with K11_HEPFAIL died.

Mortality risk

Mortality risk for people of age

years, who have K11_HEPFAIL.

N-year risk Females Males
1 0.605% 0.979%
5 3.398% 8.39%
10 9.095% 20.469%
15 16.851% 36.282%
20 27.438% 53.177%

Relationships between endpoints

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Index endpoint: K11_HEPFAIL – Hepatic failure, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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