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Other inflammatory liver diseases

DOID EFO Endpoint Browser PheWeb

K11_OTHINFLIV

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K75
  • Hospital discharge: ICD-9 — 5720A
  • Hospital discharge: ICD-8 — 57300
  • Cause of death: ICD-10 — K75
  • Cause of death: ICD-9 — 5720A
  • Cause of death: ICD-8 — 57300

2 out of 7 registries used, show all original rules.

2326

4. Check minimum number of events

None

2326

5. Include endpoints

None

2326

6. Filter based on genotype QC (FinnGen only)

2238

Control definitions (FinnGen only)

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Alii morbi inflammatorii hepatis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19596 10245 9148
Only index persons 16233 8849 7384
Unadjusted period prevalence (%)
Whole population 0.27 0.29 0.26
Only index persons 0.31 0.33 0.28
Median age at first event (years)
Whole population 52.11 54.22 49.73
Only index persons 50.76 52.78 48.34

-FinnGen-

Key figures

All Female Male
Number of individuals 2238 1289 949
Unadjusted period prevalence (%) 0.49 0.51 0.48
Median age at first event (years) 51.03 50.60 51.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHINFLIV and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHINFLIV 2.225 [2.0, 2.48] < 0.001
Birth year 0.992 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 1869 out of 7701 females with K11_OTHINFLIV died.

Males

Parameter HR [95% CI] p-value
K11_OTHINFLIV 2.653 [2.38, 2.96] < 0.001
Birth year 0.989 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 2097 out of 6647 males with K11_OTHINFLIV died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHINFLIV.

N-year risk Females Males
1 0.17% 0.497%
5 1.218% 3.408%
10 2.785% 7.77%
15 5.34% 13.998%
20 9.612% 24.056%

Relationships between endpoints

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Index endpoint: K11_OTHINFLIV – Other inflammatory liver diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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