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Chronic hepatitis, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

K11_CHRONHEP

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K73
  • Hospital discharge: ICD-9 — 5714A|5714X
  • Hospital discharge: ICD-8 — 57001
  • Cause of death: ICD-10 — K73
  • Cause of death: ICD-9 — 5714A|5714X
  • Cause of death: ICD-8 — 57001

2 out of 7 registries used, show all original rules.

1128

4. Check minimum number of events

None

1128

5. Include endpoints

None

1128

6. Filter based on genotype QC (FinnGen only)

1089

Control definitions (FinnGen only)

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Hepatitis chronica non alibi classificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7890 4726 3100
Only index persons 6673 4123 2550
Unadjusted period prevalence (%)
Whole population 0.12 0.14 0.09
Only index persons 0.13 0.15 0.10
Median age at first event (years)
Whole population 55.74 57.47 53.03
Only index persons 54.41 56.19 51.54

-FinnGen-

Key figures

All Female Male
Number of individuals 1089 711 378
Unadjusted period prevalence (%) 0.25 0.28 0.19
Median age at first event (years) 54.49 54.25 54.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_CHRONHEP and mortality.

Females

Parameter HR [95% CI] p-value
K11_CHRONHEP 2.604 [2.3, 2.95] < 0.001
Birth year 0.994 [0.99, 1.0] 0.142

During the follow-up period (1.1.1998 — 31.12.2019), 918 out of 3652 females with K11_CHRONHEP died.

Males

Parameter HR [95% CI] p-value
K11_CHRONHEP 3.327 [2.86, 3.87] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 739 out of 2256 males with K11_CHRONHEP died.

Mortality risk

Mortality risk for people of age

years, who have K11_CHRONHEP.

N-year risk Females Males
1 0.215% 0.576%
5 1.371% 4.121%
10 3.587% 9.979%
15 6.769% 19.304%
20 12.043% 30.726%

Relationships between endpoints

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Index endpoint: K11_CHRONHEP – Chronic hepatitis, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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