No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
423 |
4. Check minimum number of eventsNone |
423 |
5. Include endpointsNone |
423 |
6. Filter based on genotype QC (FinnGen only) |
408 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Chronic hepatitis NAS
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3280 | 1919 | 1341 |
| Only index persons | 2815 | 1703 | 1112 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.85 | 57.41 | 53.52 |
| Only index persons | 54.73 | 56.41 | 52.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 408 | 266 | 142 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 53.26 | 52.85 | 54.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint CHRONHEP_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 2.925 [2.5, 3.42] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 1704 females with CHRONHEP_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONHEP_NAS | 3.58 [2.98, 4.31] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 1151 males with CHRONHEP_NAS died.
Mortality risk
Mortality risk for people of age
years, who have CHRONHEP_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.504% |
| 5 | 1.625% | 3.958% |
| 10 | 3.561% | 9.484% |
| 15 | 6.913% | 18.168% |
| 20 | 12.624% | 29.866% |
Relationships between endpoints
↥Index endpoint: CHRONHEP_NAS – Chronic hepatitis NAS
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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