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Other diseases of liver

DOID EFO Endpoint Browser PheWeb

K11_DISLIVOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K76
  • Hospital discharge: ICD-9 — 571[8-9]|572[1-8]
  • Hospital discharge: ICD-8 — 573
  • Hospital discharge: excluded ICD-8 — 57300
  • Cause of death: ICD-10 — K76
  • Cause of death: ICD-9 — 571[8-9]|572[1-8]
  • Cause of death: ICD-8 — 573
  • Cause of death: excluded ICD-8 — 57300

2 out of 7 registries used, show all original rules.

6674

4. Check minimum number of events

None

6674

5. Include endpoints

None

6674

6. Filter based on genotype QC (FinnGen only)

6414

Control definitions (FinnGen only)

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Alii morbi hepatis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 50059 25246 24253
Only index persons 41488 21818 19670
Unadjusted period prevalence (%)
Whole population 0.70 0.72 0.68
Only index persons 0.78 0.80 0.75
Median age at first event (years)
Whole population 54.21 56.63 51.66
Only index persons 53.46 55.95 50.69

-FinnGen-

Key figures

All Female Male
Number of individuals 6414 3691 2723
Unadjusted period prevalence (%) 1.41 1.45 1.37
Median age at first event (years) 53.86 54.25 53.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_DISLIVOTH and mortality.

Females

Parameter HR [95% CI] p-value
K11_DISLIVOTH 1.937 [1.75, 2.14] < 0.001
Birth year 0.994 [0.99, 1.0] 0.148

During the follow-up period (1.1.1998 — 31.12.2019), 3010 out of 16846 females with K11_DISLIVOTH died.

Males

Parameter HR [95% CI] p-value
K11_DISLIVOTH 2.603 [2.33, 2.91] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 3414 out of 14209 males with K11_DISLIVOTH died.

Mortality risk

Mortality risk for people of age

years, who have K11_DISLIVOTH.

N-year risk Females Males
1 0.158% 0.541%
5 1.143% 3.029%
10 2.605% 7.458%
15 5.145% 13.69%
20 8.913% 21.795%

Relationships between endpoints

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Index endpoint: K11_DISLIVOTH – Other diseases of liver

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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