portal hypertension: Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
91 |
4. Check minimum number of eventsNone |
91 |
5. Include endpointsNone |
91 |
6. Filter based on genotype QC (FinnGen only) |
88 |
Control definitions (FinnGen only)
Control exclude
CIRRHOSIS_BROAD
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K76
Name in latin
Hypertensio venae portae
Similar endpoints
↥List of similar endpoints to
Hypertension, portal
based on the number of shared cases.
Similar with more cases:
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Other diseases of liver
- Diseases of liver
- Gastrointestinal diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 745 | 296 | 439 |
| Only index persons | 603 | 241 | 362 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.88 | 59.75 | 58.18 |
| Only index persons | 58.65 | 58.48 | 58.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 88 | 38 | 50 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 57.43 | 57.76 | 57.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_HYPTENSPOR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPOR | 11.525 [6.2, 21.42] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.111 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 189 females with I9_HYPTENSPOR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_HYPTENSPOR | 8.06 [4.37, 14.86] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 292 males with I9_HYPTENSPOR died.
Mortality risk
Mortality risk for people of age
years, who have I9_HYPTENSPOR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.019% | 1.869% |
| 5 | 5.916% | 9.495% |
| 10 | 14.89% | 22.671% |
| 15 | 26.58% | 39.024% |
| 20 | 41.417% | 57.582% |
Relationships between endpoints
↥Index endpoint: I9_HYPTENSPOR – Hypertension, portal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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