non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3146 |
4. Check minimum number of eventsNone |
3146 |
5. Include endpointsNone |
3146 |
6. Filter based on genotype QC (FinnGen only) |
3006 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K76
Name in latin
Degeneratio adiposa hepatis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Nonalcoholic fatty liver disease
based on the number of shared cases.
Similar with more cases:
- Other diseases of liver
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18945 | 9005 | 9846 |
| Only index persons | 18156 | 8715 | 9441 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.26 | 0.28 |
| Only index persons | 0.34 | 0.32 | 0.36 |
| Median age at first event (years) | |||
| Whole population | 52.61 | 56.47 | 49.12 |
| Only index persons | 52.46 | 56.38 | 48.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3006 | 1707 | 1299 |
| Unadjusted period prevalence (%) | 0.66 | 0.67 | 0.65 |
| Median age at first event (years) | 54.50 | 55.52 | 53.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint NAFLD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NAFLD | 2.01 [1.77, 2.28] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 867 out of 7023 females with NAFLD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NAFLD | 2.179 [1.91, 2.48] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1066 out of 7507 males with NAFLD died.
Mortality risk
Mortality risk for people of age
years, who have NAFLD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.401% |
| 5 | 1.033% | 2.268% |
| 10 | 2.558% | 5.635% |
| 15 | 5.085% | 10.176% |
| 20 | 9.129% | 16.963% |
Relationships between endpoints
↥Index endpoint: NAFLD – Nonalcoholic fatty liver disease
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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