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Alcoholic liver disease

DOID Endpoint Browser

ALCOLIVER

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K70
  • Hospital discharge: ICD-9 — 571[0-3]
  • Hospital discharge: ICD-8 — 5710
  • Cause of death: ICD-10 — K70
  • Cause of death: ICD-9 — 571[0-3]
  • Cause of death: ICD-8 — 5710

2 out of 7 registries used, show all original rules.

3413

4. Check minimum number of events

None

3413

5. Include endpoints

None

3413

6. Filter based on genotype QC (FinnGen only)

3330

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Morbus hepatis alcoholicus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 3330 826 2504
Unadjusted period prevalence (%) 1.03 0.32 1.26
Median age at first event (years) 58.37 56.20 59.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: ALCOLIVER – Alcoholic liver disease

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).