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Fibrosis and cirrhosis of liver

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K11_FIBROCHIRLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K74
  • Hospital discharge: ICD-9 — 571[5-6]
  • Hospital discharge: ICD-8 — 5719
  • Cause of death: ICD-10 — K74
  • Cause of death: ICD-9 — 571[5-6]
  • Cause of death: ICD-8 — 5719

2 out of 7 registries used, show all original rules.

2418

4. Check minimum number of events

None

2418

5. Include endpoints

None

2418

6. Filter based on genotype QC (FinnGen only)

2338

Control definitions (FinnGen only)

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Fibrosis et cirrhosis hepatis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23725 11371 11894
Only index persons 16446 8181 8265
Unadjusted period prevalence (%)
Whole population 0.33 0.33 0.33
Only index persons 0.31 0.30 0.32
Median age at first event (years)
Whole population 63.88 64.27 63.53
Only index persons 63.60 63.15 64.04

-FinnGen-

Key figures

All Female Male
Number of individuals 2338 1223 1115
Unadjusted period prevalence (%) 0.52 0.48 0.56
Median age at first event (years) 62.36 60.15 64.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_FIBROCHIRLIV and mortality.

Females

Parameter HR [95% CI] p-value
K11_FIBROCHIRLIV 4.932 [4.37, 5.57] < 0.001
Birth year 0.991 [0.98, 1.0] 0.028

During the follow-up period (1.1.1998 — 31.12.2019), 2888 out of 6837 females with K11_FIBROCHIRLIV died.

Males

Parameter HR [95% CI] p-value
K11_FIBROCHIRLIV 7.217 [6.12, 8.51] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3915 out of 6725 males with K11_FIBROCHIRLIV died.

Mortality risk

Mortality risk for people of age

years, who have K11_FIBROCHIRLIV.

N-year risk Females Males
1 0.42% 1.153%
5 2.374% 6.99%
10 6.022% 16.152%
15 11.499% 29.88%
20 19.055% 47.457%

Relationships between endpoints

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Index endpoint: K11_FIBROCHIRLIV – Fibrosis and cirrhosis of liver

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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