non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1520 |
4. Check minimum number of eventsNone |
1520 |
5. Include endpointsNone |
1520 |
6. Filter based on genotype QC (FinnGen only) |
1470 |
Control definitions (FinnGen only)
Control exclude
CIRRHOSIS_BROAD
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K74
Name in latin
Cirrhosis hepatis alia sive non specificata
Similar endpoints
↥List of similar endpoints to
Cirrhosis of liver, NAS
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15092 | 5951 | 8918 |
| Only index persons | 11422 | 4569 | 6853 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.17 | 0.25 |
| Only index persons | 0.22 | 0.17 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 66.47 | 68.55 | 65.01 |
| Only index persons | 66.10 | 67.59 | 65.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1470 | 589 | 881 |
| Unadjusted period prevalence (%) | 0.36 | 0.23 | 0.44 |
| Median age at first event (years) | 65.84 | 65.22 | 66.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHIRHEP_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRHEP_NAS | 8.169 [6.82, 9.79] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.963 |
During the follow-up period (1.1.1998 — 31.12.2019), 2224 out of 3896 females with CHIRHEP_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRHEP_NAS | 9.397 [7.67, 11.51] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3499 out of 5661 males with CHIRHEP_NAS died.
Mortality risk
Mortality risk for people of age
years, who have CHIRHEP_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.008% | 1.497% |
| 5 | 5.56% | 9.387% |
| 10 | 12.789% | 23.294% |
| 15 | 24.546% | 38.804% |
| 20 | 39.066% | 57.792% |
Relationships between endpoints
↥Index endpoint: CHIRHEP_NAS – Cirrhosis of liver, NAS
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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