cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
195 |
4. Check minimum number of eventsNone |
195 |
5. Include endpointsNone |
195 |
6. Filter based on genotype QC (FinnGen only) |
188 |
Control definitions (FinnGen only)
Control exclude
CIRRHOSIS_BROAD
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K74
Name in latin
Fibrosis hepatis
Similar endpoints
↥List of similar endpoints to
Fibrosis of liver
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1501 | 735 | 747 |
| Only index persons | 1232 | 625 | 607 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.22 | 59.75 | 58.57 |
| Only index persons | 58.22 | 58.24 | 58.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 188 | 98 | 90 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | 57.26 | 55.45 | 59.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint FIBROLIV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FIBROLIV | 3.993 [3.15, 5.06] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.94 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 599 females with FIBROLIV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FIBROLIV | 5.7 [4.11, 7.91] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 263 out of 545 males with FIBROLIV died.
Mortality risk
Mortality risk for people of age
years, who have FIBROLIV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 1.014% |
| 5 | 2.546% | 5.439% |
| 10 | 6.983% | 14.34% |
| 15 | 12.573% | 25.688% |
| 20 | 21.768% | 40.077% |
Relationships between endpoints
↥Index endpoint: FIBROLIV – Fibrosis of liver
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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