No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
483 |
4. Check minimum number of eventsNone |
483 |
5. Include endpointsNone |
483 |
6. Filter based on genotype QC (FinnGen only) |
464 |
Control definitions (FinnGen only)
Control exclude
K11_LIVER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K70-K77
Name in latin
Morbus hepatis toxicus
Toxic liver disease
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3897 | 2092 | 1772 |
| Only index persons | 3296 | 1812 | 1484 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.05 |
| Only index persons | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 56.47 | 57.86 | 54.71 |
| Only index persons | 55.21 | 56.21 | 53.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 464 | 270 | 194 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.10 |
| Median age at first event (years) | 55.26 | 54.23 | 56.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint K11_TOXLIV and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_TOXLIV | 2.305 [1.95, 2.72] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.287 |
During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 1710 females with K11_TOXLIV died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_TOXLIV | 3.07 [2.52, 3.74] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 519 out of 1402 males with K11_TOXLIV died.
Mortality risk
Mortality risk for people of age
years, who have K11_TOXLIV.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.296% | 0.643% |
| 5 | 1.451% | 3.723% |
| 10 | 3.399% | 8.851% |
| 15 | 6.4% | 17.475% |
| 20 | 11.149% | 28.193% |
Relationships between endpoints
↥Index endpoint: K11_TOXLIV – Toxic liver disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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