No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
755 |
4. Check minimum number of eventsNone |
755 |
5. Include endpointsNone |
755 |
6. Filter based on genotype QC (FinnGen only) |
733 |
Control definitions (FinnGen only)
Control exclude
ST19_TOXIC_EFFEC_SUBST_CHIEF_NONME_SOURCE
Extra metadata
Level in the ICD hierarchy
3
Special
ALCOTOXIC
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T51-T65
Name in latin
Effectus alcoholicus toxicus
Similar endpoints
↥List of similar endpoints to
Toxic effect of alcohol
based on the number of shared cases.
Similar with more cases:
- Toxic effects of substances chiefly nonmedicinal as to source
- Alcohol use disorder, Swedish definition
- Alcohol related diseases and deaths, all endpoints
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10946 | 3014 | 7772 |
| Only index persons | 7769 | 2497 | 5272 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.09 | 0.22 |
| Only index persons | 0.17 | 0.09 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 28.20 | 21.94 | 30.22 |
| Only index persons | 22.55 | 19.17 | 24.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 733 | 264 | 469 |
| Unadjusted period prevalence (%) | 0.19 | 0.10 | 0.24 |
| Median age at first event (years) | 25.54 | 20.25 | 28.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ST19_TOXIC_EFFECT_ALCOHOL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_TOXIC_EFFECT_ALCOHOL | 4.993 [3.52, 7.08] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 999 females with ST19_TOXIC_EFFECT_ALCOHOL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_TOXIC_EFFECT_ALCOHOL | 5.096 [4.25, 6.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 587 out of 2166 males with ST19_TOXIC_EFFECT_ALCOHOL died.
Mortality risk
Mortality risk for people of age
years, who have ST19_TOXIC_EFFECT_ALCOHOL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.512% | 0.933% |
| 5 | 2.421% | 5.27% |
| 10 | 6.017% | 13.689% |
| 15 | 11.05% | 24.353% |
| 20 | 18.141% | 38.048% |
Relationships between endpoints
↥Index endpoint: ST19_TOXIC_EFFECT_ALCOHOL – Toxic effect of alcohol
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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