alcoholic pancreatitis: Acute or chronic inflammation of the pancreas due to excessive alcohol drinking. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1168 |
4. Check minimum number of eventsNone |
1168 |
5. Include endpointsNone |
1168 |
6. Filter based on genotype QC (FinnGen only) |
1144 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K85
Similar endpoints
↥List of similar endpoints to
Alcohol-induced acute pancreatitis
based on the number of shared cases.
Similar with more cases:
- Acute pancreatitis
- Acute pancreatitis (for exclusion)
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13938 | 2274 | 11487 |
| Only index persons | 9836 | 1787 | 8049 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.07 | 0.32 |
| Only index persons | 0.26 | 0.07 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 45.74 | 48.04 | 45.21 |
| Only index persons | 46.50 | 48.71 | 46.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1144 | 208 | 936 |
| Unadjusted period prevalence (%) | 0.40 | 0.08 | 0.47 |
| Median age at first event (years) | 48.71 | 48.47 | 48.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ALCOPANCACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALCOPANCACU | 4.5 [2.55, 7.94] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.196 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 815 females with ALCOPANCACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ALCOPANCACU | 3.965 [3.18, 4.95] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 456 out of 3511 males with ALCOPANCACU died.
Mortality risk
Mortality risk for people of age
years, who have ALCOPANCACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.291% | 0.681% |
| 5 | 3.029% | 4.904% |
| 10 | 6.421% | 12.006% |
| 15 | 12.055% | 21.085% |
| 20 | 20.524% | 33.046% |
Relationships between endpoints
↥Index endpoint: ALCOPANCACU – Alcohol-induced acute pancreatitis
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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