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Acute pancreatitis

DOID EFO Endpoint Browser PheWeb

K11_ACUTPANC

acute pancreatitis: An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K85
  • Hospital discharge: ICD-9 — 5770
  • Hospital discharge: ICD-8 — 5770
  • Cause of death: ICD-10 — K85
  • Cause of death: ICD-9 — 5770
  • Cause of death: ICD-8 — 5770

2 out of 7 registries used, show all original rules.

7812

4. Check minimum number of events

None

7812

5. Include endpoints

None

7812

6. Filter based on genotype QC (FinnGen only)

7562

Control definitions (FinnGen only)

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K80-K87
Name in latin Pancreatitis acuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 81729 31416 49217
Only index persons 62108 25645 36463
Unadjusted period prevalence (%)
Whole population 1.19 0.90 1.38
Only index persons 1.21 0.94 1.39
Median age at first event (years)
Whole population 54.14 58.68 51.26
Only index persons 53.87 56.99 51.68

-FinnGen-

Key figures

All Female Male
Number of individuals 7562 2963 4599
Unadjusted period prevalence (%) 1.86 1.16 2.31
Median age at first event (years) 54.15 53.20 54.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_ACUTPANC and mortality.

Females

Parameter HR [95% CI] p-value
K11_ACUTPANC 1.589 [1.46, 1.73] < 0.001
Birth year 0.996 [0.99, 1.0] 0.269

During the follow-up period (1.1.1998 — 31.12.2019), 5212 out of 18384 females with K11_ACUTPANC died.

Males

Parameter HR [95% CI] p-value
K11_ACUTPANC 2.022 [1.84, 2.23] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 7862 out of 25975 males with K11_ACUTPANC died.

Mortality risk

Mortality risk for people of age

years, who have K11_ACUTPANC.

N-year risk Females Males
1 0.138% 0.372%
5 0.92% 2.266%
10 2.36% 5.872%
15 4.55% 10.543%
20 8.059% 17.277%

Relationships between endpoints

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Index endpoint: K11_ACUTPANC – Acute pancreatitis

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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