No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1512 |
4. Check minimum number of eventsNone |
1512 |
5. Include endpointsNone |
1512 |
6. Filter based on genotype QC (FinnGen only) |
1454 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
Special
ALCOETHTOXIC
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
T51
Name in latin
Effectus toxicus alcohol aethylici
Similar endpoints
↥List of similar endpoints to
Toxic effect of ethanol
based on the number of shared cases.
Similar with more cases:
- Alcohol use disorder, Swedish definition
- Alcohol related diseases and deaths, all endpoints
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23765 | 8683 | 14891 |
| Only index persons | 19385 | 7778 | 11607 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.35 | 0.25 | 0.42 |
| Only index persons | 0.38 | 0.29 | 0.44 |
| Median age at first event (years) | |||
| Whole population | 21.51 | 15.84 | 24.50 |
| Only index persons | 17.62 | 15.58 | 18.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1454 | 664 | 790 |
| Unadjusted period prevalence (%) | 0.33 | 0.26 | 0.40 |
| Median age at first event (years) | 23.32 | 16.16 | 29.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ST19_TOXIC_EFFECT_ETHAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_TOXIC_EFFECT_ETHAN | 5.261 [4.21, 6.57] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.899 |
During the follow-up period (1.1.1998 — 31.12.2019), 320 out of 4850 females with ST19_TOXIC_EFFECT_ETHAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ST19_TOXIC_EFFECT_ETHAN | 5.615 [4.99, 6.32] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1168 out of 6850 males with ST19_TOXIC_EFFECT_ETHAN died.
Mortality risk
Mortality risk for people of age
years, who have ST19_TOXIC_EFFECT_ETHAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.708% | 1.109% |
| 5 | 3.474% | 6.285% |
| 10 | 7.41% | 14.344% |
| 15 | 13.925% | 25.662% |
| 20 | 25.639% | 39.088% |
Relationships between endpoints
↥Index endpoint: ST19_TOXIC_EFFECT_ETHAN – Toxic effect of ethanol
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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