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Alcohol induced polyneuropathy

ALCOPOLYNEU

alcoholic neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G62.1
  • Hospital discharge: ICD-9 3575A
  • Cause of death: ICD-10 G62.1
  • Cause of death: ICD-9 3575A

2 out of 7 registries used, show all original rules.

303

4. Check minimum number of events

None

303

5. Include endpoints

None

303

6. Filter based on genotype QC (FinnGen only)

293

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G62
Name in latin Polyneuropathia alcoholica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 293 57 236
Unadjusted period prevalence (%) 0.10 0.02 0.12
Median age at first event (years) 58.19 55.23 58.91

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: ALCOPOLYNEU – Alcohol induced polyneuropathy

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).