No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
721 |
4. Check minimum number of eventsNone |
721 |
5. Include endpointsNone |
721 |
6. Filter based on genotype QC (FinnGen only) |
697 |
Control definitions (FinnGen only)
Control exclude
G6_NEURODEG
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G31
Name in latin
Degeneratio systematis nervosi ex alcohol (aethylico)
Similar endpoints
↥List of similar endpoints to
Degeneration of the brain due to alcohol
based on the number of shared cases.
Similar with more cases:
- Degeneration of nervous system due to alcohol
- Other degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12921 | 2765 | 9998 |
| Only index persons | 10336 | 2353 | 7983 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.08 | 0.28 |
| Only index persons | 0.26 | 0.09 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 58.75 | 58.87 | 58.62 |
| Only index persons | 58.94 | 59.19 | 58.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 697 | 112 | 585 |
| Unadjusted period prevalence (%) | 0.25 | 0.04 | 0.29 |
| Median age at first event (years) | 59.57 | 57.66 | 59.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALCODEGEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCODEGEN | 7.086 [6.16, 8.15] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.159 |
During the follow-up period (1.1.1998 — 31.12.2019), 1024 out of 2337 females with G6_ALCODEGEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCODEGEN | 5.864 [5.32, 6.46] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 4483 out of 8289 males with G6_ALCODEGEN died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALCODEGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.797% | 1.179% |
| 5 | 3.618% | 6.351% |
| 10 | 9.524% | 14.645% |
| 15 | 18.008% | 27.105% |
| 20 | 29.468% | 41.761% |
Relationships between endpoints
↥Index endpoint: G6_ALCODEGEN – Degeneration of the brain due to alcohol
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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