No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
16821 |
4. Check minimum number of eventsNone |
16821 |
5. Include endpoints |
16991 |
6. Filter based on genotype QC (FinnGen only) |
16347 |
Control definitions (FinnGen only)
Control exclude
NEURODIS
Extra metadata
First used in FinnGen datafreeze
DF2
Other degenerative diseases of the nervous system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 276325 | 168911 | 105057 |
| Only index persons | 228452 | 143276 | 85176 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.09 | 4.84 | 2.94 |
| Only index persons | 4.52 | 5.27 | 3.25 |
| Median age at first event (years) | |||
| Whole population | 80.45 | 81.70 | 78.52 |
| Only index persons | 80.95 | 82.09 | 79.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16347 | 8088 | 8259 |
| Unadjusted period prevalence (%) | 3.67 | 3.18 | 4.15 |
| Median age at first event (years) | 76.71 | 75.33 | 78.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint NEURODEGOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NEURODEGOTH | 2.553 [2.33, 2.79] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 78730 out of 129205 females with NEURODEGOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NEURODEGOTH | 3.045 [2.7, 3.44] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 50139 out of 78476 males with NEURODEGOTH died.
Mortality risk
Mortality risk for people of age
years, who have NEURODEGOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.379% |
| 5 | 0.942% | 2.318% |
| 10 | 2.505% | 6.245% |
| 15 | 4.559% | 11.722% |
| 20 | 7.723% | 18.875% |
Relationships between endpoints
↥Index endpoint: NEURODEGOTH – Other degenerative diseases of the nervous system
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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