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Other and unspecified degenerative diseases of nervous system

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G6_DEGENOTH

Lewy body dementia: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G31.8, G31.9, G32*
  • Hospital discharge: ICD-9 — 331[8-9]
  • Hospital discharge: ICD-8 — 32303
  • Cause of death: ICD-10 — G31.8, G31.9, G32*
  • Cause of death: ICD-9 — 331[8-9]
  • Cause of death: ICD-8 — 32303

2 out of 7 registries used, show all original rules.

722

4. Check minimum number of events

None

722

5. Include endpoints

None

722

6. Filter based on genotype QC (FinnGen only)

698

Control definitions (FinnGen only)

Control exclude G6_NEURODEG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10790 5168 5413
Only index persons 7351 3692 3659
Unadjusted period prevalence (%)
Whole population 0.15 0.15 0.15
Only index persons 0.14 0.14 0.14
Median age at first event (years)
Whole population 74.25 75.65 72.93
Only index persons 74.27 75.65 72.88

-FinnGen-

Key figures

All Female Male
Number of individuals 698 273 425
Unadjusted period prevalence (%) 0.17 0.11 0.21
Median age at first event (years) 71.78 70.59 72.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_DEGENOTH and mortality.

Females

Parameter HR [95% CI] p-value
G6_DEGENOTH 3.447 [3.0, 3.96] < 0.001
Birth year 0.997 [0.99, 1.01] 0.576

During the follow-up period (1.1.1998 — 31.12.2019), 2005 out of 3191 females with G6_DEGENOTH died.

Males

Parameter HR [95% CI] p-value
G6_DEGENOTH 3.577 [3.04, 4.2] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2129 out of 3230 males with G6_DEGENOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_DEGENOTH.

N-year risk Females Males
1 0.489% 0.688%
5 2.564% 3.686%
10 5.012% 9.047%
15 9.392% 16.18%
20 16.978% 26.346%

Relationships between endpoints

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Index endpoint: G6_DEGENOTH – Other and unspecified degenerative diseases of nervous system

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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