No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
603 |
4. Check minimum number of eventsNone |
603 |
5. Include endpointsNone |
603 |
6. Filter based on genotype QC (FinnGen only) |
579 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Circumscribed brain atrophy based on the number of shared cases.
Similar with more cases:
- Other degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 9185 | 4538 | 4462 |
Only index persons | 6588 | 3580 | 3008 |
Unadjusted period prevalence (%) | |||
Whole population | 0.13 | 0.13 | 0.12 |
Only index persons | 0.12 | 0.13 | 0.11 |
Median age at first event (years) | |||
Whole population | 66.45 | 69.56 | 63.74 |
Only index persons | 69.18 | 70.86 | 67.17 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 579 | 250 | 329 |
Unadjusted period prevalence (%) | 0.14 | 0.10 | 0.17 |
Median age at first event (years) | 67.03 | 66.94 | 67.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ATROPHCIRCUM and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
G6_ATROPHCIRCUM | 3.807 [3.24, 4.47] | < 0.001 |
Birth year | 0.996 [0.99, 1.0] | 0.335 |
During the follow-up period (1.1.1998 — 31.12.2019), 1496 out of 2867 females with G6_ATROPHCIRCUM died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
G6_ATROPHCIRCUM | 3.818 [3.16, 4.61] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.052 |
During the follow-up period (1.1.1998 — 31.12.2019), 1262 out of 2230 males with G6_ATROPHCIRCUM died.
Mortality risk
Mortality risk for people of age
years, who have G6_ATROPHCIRCUM.N-year risk | Females | Males |
---|---|---|
1 | 0.352% | 0.706% |
5 | 2.162% | 4.74% |
10 | 5.576% | 11.668% |
15 | 10.637% | 21.832% |
20 | 18.658% | 34.354% |
Relationships between endpoints
↥Index endpoint: G6_ATROPHCIRCUM – Circumscribed brain atrophy
GWS hits: 1