Circumscribed brain atrophy

G6_ATROPHCIRCUM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G31.0
  • Hospital discharge: ICD-9 3311
  • Hospital discharge: ICD-8 34791
  • Cause of death: ICD-10 G31.0
  • Cause of death: ICD-9 3311
  • Cause of death: ICD-8 34791

2 out of 7 registries used, show all original rules.

603

4. Check minimum number of events

None

603

5. Include endpoints

None

603

6. Filter based on genotype QC (FinnGen only)

579

Control definitions (FinnGen only)

Control exclude G6_NEURODEG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6
Parent code in ICD-10 G31
Name in latin Atrophia cerebri circumscripta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9185 4538 4462
Only index persons 6588 3580 3008
Unadjusted period prevalence (%)
Whole population 0.13 0.13 0.12
Only index persons 0.12 0.13 0.11
Median age at first event (years)
Whole population 66.45 69.56 63.74
Only index persons 69.18 70.86 67.17

-FinnGen-

Key figures

All Female Male
Number of individuals 579 250 329
Unadjusted period prevalence (%) 0.14 0.10 0.17
Median age at first event (years) 67.03 66.94 67.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint G6_ATROPHCIRCUM and mortality.

Females

Parameter HR [95% CI] p-value
G6_ATROPHCIRCUM 3.807 [3.24, 4.47] < 0.001
Birth year 0.996 [0.99, 1.0] 0.335

During the follow-up period (1.1.1998 — 31.12.2019), 1496 out of 2867 females with G6_ATROPHCIRCUM died.

Males

Parameter HR [95% CI] p-value
G6_ATROPHCIRCUM 3.818 [3.16, 4.61] < 0.001
Birth year 0.991 [0.98, 1.0] 0.052

During the follow-up period (1.1.1998 — 31.12.2019), 1262 out of 2230 males with G6_ATROPHCIRCUM died.

Mortality risk

Mortality risk for people of age

years, who have G6_ATROPHCIRCUM.

N-year risk Females Males
1 0.352% 0.706%
5 2.162% 4.74%
10 5.576% 11.668%
15 10.637% 21.832%
20 18.658% 34.354%

Relationships between endpoints

Index endpoint: G6_ATROPHCIRCUM – Circumscribed brain atrophy

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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