No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
148 |
4. Check minimum number of eventsNone |
148 |
5. Include endpointsNone |
148 |
6. Filter based on genotype QC (FinnGen only) |
145 |
Control definitions (FinnGen only)
Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Frontotemporal dementia
based on the number of shared cases.
Similar with more cases:
- Frontotemporal dementia, wide, incl. Pick's disease
- Circumscribed brain atrophy
- Dementia in other diseases classified elsewhere
- Other degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2112 | 1189 | 909 |
| Only index persons | 1877 | 1084 | 793 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 71.43 | 72.17 | 70.41 |
| Only index persons | 71.37 | 72.13 | 70.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 145 | 65 | 80 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 69.58 | 69.48 | 69.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint FTD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FTD | 3.562 [2.87, 4.42] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.253 |
During the follow-up period (1.1.1998 — 31.12.2019), 577 out of 1114 females with FTD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FTD | 4.074 [3.11, 5.33] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 493 out of 822 males with FTD died.
Mortality risk
Mortality risk for people of age
years, who have FTD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.343% | 0.872% |
| 5 | 2.068% | 5.012% |
| 10 | 5.094% | 12.523% |
| 15 | 9.351% | 21.829% |
| 20 | 15.906% | 34.13% |
Relationships between endpoints
↥Index endpoint: FTD – Frontotemporal dementia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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