obsolete_dementia: ['An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
4 out of 7 registries used, show all original rules. |
21426 |
4. Check minimum number of events
Min. number of events
3
|
21426 |
5. Include endpoints |
21460 |
6. Filter based on genotype QC (FinnGen only) |
20667 |
Control definitions (FinnGen only)
Control exclude
F5_ORGANIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF3
Dementia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 412960 | 252777 | 155854 |
| Only index persons | 305996 | 191151 | 114845 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.12 | 7.24 | 4.35 |
| Only index persons | 6.04 | 7.03 | 4.38 |
| Median age at first event (years) | |||
| Whole population | 80.88 | 81.84 | 79.37 |
| Only index persons | 81.10 | 82.08 | 79.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 20667 | 9040 | 11627 |
| Unadjusted period prevalence (%) | 4.84 | 3.55 | 5.84 |
| Median age at first event (years) | 78.82 | 79.16 | 78.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_DEMENTIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_DEMENTIA | 2.556 [2.35, 2.78] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 123209 out of 192688 females with F5_DEMENTIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_DEMENTIA | 2.794 [2.5, 3.12] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 76869 out of 117357 males with F5_DEMENTIA died.
Mortality risk
Mortality risk for people of age
years, who have F5_DEMENTIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.187% | 0.43% |
| 5 | 1.061% | 2.292% |
| 10 | 2.599% | 5.449% |
| 15 | 4.58% | 10.147% |
| 20 | 7.419% | 16.761% |
Relationships between endpoints
↥Index endpoint: F5_DEMENTIA – Dementia
GWS hits: 15
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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