vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3224 |
4. Check minimum number of eventsNone |
3224 |
5. Include endpointsNone |
3224 |
6. Filter based on genotype QC (FinnGen only) |
3116 |
Control definitions (FinnGen only)
Control exclude
F5_DEMENTIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F00-F03
Name in latin
Dementia vascularis
Similar endpoints
↥List of similar endpoints to
Vascular dementia
based on the number of shared cases.
Similar with more cases:
- Dementia
- Dementia, including avohilmo
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 65659 | 37270 | 27252 |
| Only index persons | 40397 | 23852 | 16545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.94 | 1.07 | 0.76 |
| Only index persons | 0.78 | 0.88 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 82.41 | 84.09 | 80.27 |
| Only index persons | 83.66 | 85.41 | 81.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3116 | 1105 | 2011 |
| Unadjusted period prevalence (%) | 0.81 | 0.43 | 1.01 |
| Median age at first event (years) | 80.62 | 82.63 | 79.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_VASCDEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_VASCDEM | 2.669 [2.37, 3.01] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.188 |
During the follow-up period (1.1.1998 — 31.12.2019), 15971 out of 21397 females with F5_VASCDEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_VASCDEM | 3.066 [2.63, 3.58] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 11786 out of 15677 males with F5_VASCDEM died.
Mortality risk
Mortality risk for people of age
years, who have F5_VASCDEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.66% |
| 5 | 1.301% | 3.649% |
| 10 | 3.382% | 8.705% |
| 15 | 6.703% | 15.866% |
| 20 | 11.875% | 26.392% |
Relationships between endpoints
↥Index endpoint: F5_VASCDEM – Vascular dementia
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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