vascular dementia: A degenerative vascular disorder affecting the brain. It is caused by the blockage of the blood supply to the brain. It is manifested with decline of memory and cognitive functions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
896 |
4. Check minimum number of eventsNone |
896 |
5. Include endpointsNone |
896 |
6. Filter based on genotype QC (FinnGen only) |
874 |
Control definitions (FinnGen only)
Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F01
Name in latin
Dementia vascularis subcorticalis
Vascular dementia (subcortical)
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12884 | 7551 | 5236 |
| Only index persons | 10927 | 6528 | 4399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.15 |
| Only index persons | 0.21 | 0.24 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 82.23 | 83.77 | 80.07 |
| Only index persons | 82.70 | 84.21 | 80.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 874 | 342 | 532 |
| Unadjusted period prevalence (%) | 0.22 | 0.13 | 0.27 |
| Median age at first event (years) | 80.86 | 82.39 | 79.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint VD_SC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_SC | 2.216 [1.92, 2.56] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 3411 out of 5576 females with VD_SC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_SC | 2.752 [2.26, 3.34] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2589 out of 3954 males with VD_SC died.
Mortality risk
Mortality risk for people of age
years, who have VD_SC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.19% | 0.439% |
| 5 | 0.887% | 2.567% |
| 10 | 2.593% | 6.823% |
| 15 | 5.147% | 12.85% |
| 20 | 8.771% | 21.239% |
Relationships between endpoints
↥Index endpoint: VD_SC – Vascular dementia (subcortical)
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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