No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
KRA_PSY_ANYMENTAL
Extra metadata
First used in FinnGen datafreeze
DF9
Any dementia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 385404 | 236885 | 144096 |
| Only index persons | 275980 | 173824 | 102156 |
| Unadjusted period prevalence (%) | |||
| Whole population | 5.73 | 6.79 | 4.03 |
| Only index persons | 5.47 | 6.39 | 3.90 |
| Median age at first event (years) | |||
| Whole population | 81.77 | 82.80 | 80.17 |
| Only index persons | 82.36 | 83.39 | 80.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18216 | 7942 | 10274 |
| Unadjusted period prevalence (%) | 4.27 | 3.12 | 5.16 |
| Median age at first event (years) | 79.61 | 79.90 | 79.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_DEMENTIA_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_DEMENTIA_EXMORE | 2.914 [2.68, 3.17] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 114426 out of 165091 females with KRA_PSY_DEMENTIA_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_DEMENTIA_EXMORE | 3.312 [2.95, 3.72] | < 0.001 |
| Birth year | 0.98 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 70405 out of 98899 males with KRA_PSY_DEMENTIA_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_DEMENTIA_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.177% | 0.392% |
| 5 | 1.081% | 2.383% |
| 10 | 2.531% | 6.001% |
| 15 | 4.733% | 10.799% |
| 20 | 7.806% | 17.116% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_DEMENTIA_EXMORE – Any dementia
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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