Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
12198 |
4. Check minimum number of eventsNone |
12198 |
5. Include endpointsNone |
12198 |
6. Filter based on genotype QC (FinnGen only) |
11755 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G30-G32
Name in latin
Morbus Alzheimer
Similar endpoints
↥List of similar endpoints to
Alzheimer disease
based on the number of shared cases.
Similar with more cases:
- Alzheimer disease
- Other degenerative diseases of the nervous system
- Alzheimer disease, including avohilmo
- Other degenerative diseases of the nervous system
- Alzheimer’s disease, wide definition
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 227475 | 144794 | 80971 |
| Only index persons | 189864 | 122913 | 66951 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.46 | 4.15 | 2.26 |
| Only index persons | 3.83 | 4.52 | 2.56 |
| Median age at first event (years) | |||
| Whole population | 82.31 | 83.07 | 81.01 |
| Only index persons | 82.76 | 83.50 | 81.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11755 | 5354 | 6401 |
| Unadjusted period prevalence (%) | 2.71 | 2.10 | 3.21 |
| Median age at first event (years) | 80.28 | 80.25 | 80.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALZHEIMER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALZHEIMER | 2.419 [2.2, 2.66] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 74328 out of 110920 females with G6_ALZHEIMER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALZHEIMER | 2.756 [2.43, 3.13] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 42782 out of 61190 males with G6_ALZHEIMER died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALZHEIMER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.451% |
| 5 | 1.156% | 2.751% |
| 10 | 2.546% | 6.244% |
| 15 | 4.559% | 11.313% |
| 20 | 8.12% | 18.563% |
Relationships between endpoints
↥Index endpoint: G6_ALZHEIMER – Alzheimer disease
GWS hits: 16
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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